Yes Obviously. Smoking causes wrinkles by narrowing blood vessels in the outer layers of skin. This causes less blood flow and reduces the amount of oxygen and nutrients that can get to the skin. Smoking damages important connective fibers like collagen and elastin, causing permanent wrinkles.

Oxygen facial mask also delivers deep cleansing effect that can effectively removes dirt and makeups such as sun cream, BB cream and other foundations from our skin. This is because it contains CF-61, a new cleansing material made by advanced technology, minimize stimulation but actively removes waste and make-up residue with its oxygen bubble.

Hey,

Really, It is very hard task to select the  wrinkle cream which is best or really work. It depend on your skin. If any cream which work for one it not necessary that it work for everyone. My sister also have same problem and always wondering for best cream which made from natural ingredients.

Ulcer can be caused by several different diseases, conditions or infections.
Pyoderma gangrenosum is a rare disorder of the immune system that causes large ulcers on the skin, usually on the legs.
Bedsores are skin ulcers that are also called pressure sores.
Buerger's disease is a blood vessel disorder that causes blood clots and inflammation in the blood vessels of the arms and legs.

Some tips are:

Stay Hydrated to Get Rid of Neck Wrinkles.
Apply Neck Cream For Neck Wrinkles Treatment.
Moisturize Your Neck for Removing Neck Wrinkles.
Apply Nexifirm Creams for Getting Rid of Neck Wrinkles.
Exfoliate Your Neck Skin to Get Rid of Neck Creases

Some skin bleaching herbs are:

Chamomile, Lady Horseradish, Lady’s Mantle, Lemon Juice, Red Onions, Solomon’s Seal, Wild Strawberry and Ground Ivy Leaves.

Honey, unlike table sugar, is a natural ingredient. It contains vitamins, minerals and amino acids. These all work together to help in fat and cholesterol metabolism, and that helps prevent obesity. Honey has a healthier glycerin index (GI) than sugar.  What that means is that when you eat honey, it doesn't cause a sugar rush, but it is gradually absorbed into your body, thereby providing a stable source of energy.   Therefore, you won’t get a sugar “high” and then a “crash” afterward.

Lemon contains citric acid, which can be effective in treating acne. The vitamin C found in citrus fruits is vital for that healthy glowing skin while its alkaline nature kills some types of bacteria known to cause acne. With your finger or a cotton ball, apply fresh lemon juice on acne and leave it overnight. Wash with water the following morning. There may be an uncomfortable sensation of burning at first, but it will soon disappear. Mix one part of freshly squeezed lemon juice with an equal part of rose or honey water. Put the mixture on affected areas for at least half an hour. Wash it afterwards with water. This application should be repeated twice daily, ideally in the morning and the evening.

After applying of pepper and cinnamon oil your lips start irritating, sensation like inflaming, blood flow get increased and it get fuller for about an 2 hour.

Hey,

Please consult with your doctor, No one can give exact solution here, that may be due to allergy or may be due to infection. So it is better to consult with doctor.