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USES: Pioglitazone is an anti-diabetic drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes). It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.Pioglitazone is used either alone or in combination with other anti-diabetic medications (such as metformin or a sulfonylurea such as glyburide). This medication should not be used to treat people with type 1 diabetes (insulin-dependent diabetes).