close
    can heart damage from cocaine use be reversed?

    0  Views: 419 Answers: 1 Posted: 12 years ago

    1 Answer

    Cocaine increases myocardial oxygen demand by increasing both heart rate and blood pressure (Table 1).25,26 The influence of cocaine on heart rate and blood pressure is dose dependent and is mediated through α-adrenergic stimulation.25,26 At the same time, cocaine decreases oxygen supply via coronary vasoconstriction.25 Cocaine-induced coronary vasoconstriction occurs in normal (nondiseased) coronary artery segments but is more pronounced in atherosclerotic segments.27 Combining cocaine use with cigarette smoking has additive effects on coronary vasoconstriction while markedly increasing the rate-pressure product.28 Long-term cocaine users demonstrate coronary endothelial dysfunction.29 Because endothelial dysfunction increases the sensitivity of a vessel to the constrictor effects of catecholamines,30 it may be particularly detrimental for cocaine users. Even in the absence of epicardial coronary disease, cocaine causes microvascular disease31,32 and is associated with thrombosis.24,33,34



    Top contributors in Uncategorized category

     
    ROMOS
    Answers: 18061 / Questions: 154
    Karma: 1101K
     
    Colleen
    Answers: 47270 / Questions: 115
    Karma: 953K
     
    country bumpkin
    Answers: 11322 / Questions: 160
    Karma: 838K
     
    Benthere
    Answers: 2392 / Questions: 30
    Karma: 760K
    > Top contributors chart

    Unanswered Questions

    shbet17co
    Answers: 0 Views: 8 Rating: 0
    what is jitter test??
    Answers: 0 Views: 8 Rating: 0
    Cao thủ soi cầu 247
    Answers: 0 Views: 9 Rating: 0
    Xoilac Tv Peterpan
    Answers: 0 Views: 6 Rating: 0
    Xoilac Tv Peterpan
    Answers: 0 Views: 9 Rating: 0
    Xoilac Tv Peterpan
    Answers: 0 Views: 7 Rating: 0
    Xoilac Tv Peterpan
    Answers: 0 Views: 13 Rating: 0
    > More questions...
    452082
    questions
    719633
    answers
    753097
    users