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Running is a great form of exercise, but you need to be safe out there and to do that you must run defensively. Whether you run on the sidewalk or in the road, because asphalt is more forgiving than concrete, run against the flow of traffic. That's the left hand side of the road here in the States. Running against traffic means you can see what is coming toward you, because sometimes motorists do some unpredictable things, like pull into a driveway. You must always assume, no matter how bright your jacket is, that the driver doesn't see you. So play it safe and run toward oncoming traffic.  http://www.fitsugar.com/Safety-Tip-Run-Against-Traffic-2649319

• Run against traffic. A bicycle is considered a vehicle, so it is subject to the same laws as cars and trucks. Cyclists ride with traffic. You are not a vehicle. You are a runner. You are also in a highly vulnerable position if you're running near cars, trucks, and bicycles.

So the best way to prevent an untimely meeting with one of these vehicles is to be able to see them. That means running on the side of the road or on the sidewalk and running while facing traffic.  http://www.dummies.com/how-to/content/knowing-your-running-safety-rules.html