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Samuels was first seen onDrake & Josh during 2004 as Ashley Blake, in the episode Little Diva. She was later seen on The Suite Life of Zack & Codyand That's So Raven in 2005. She gained a 3-episode arc role onWizards of Waverly Placeas mean girl Gigi, which started in 2007 and ended the next year. She also appeared on the film The Stepfather (2009) in a supporting role.

Samuels was part of the main cast of the TV series The Gates (2010) and The Nine Lives of Chloe King(2011), both series were cancelled after one season. In 2010, Samuels appeared on Furry Vengeance, a film that was panned by critics and was a box office failure. She was also portraying Sharon #3, the female lead, on the upcoming romantic comedy film Sharon 1.2.3, alongside Matt Bush.

Samuels appeared in 4 episodes of American Horror Story: Freakshow in 2014 as Bonnie Lipton. She acted on the show alongside current co-star, Emma Roberts. From there, Ryan Murphy (creator of AHS and Scream Queens) offered her the role of Grace on Scream Queens. and is part of the 2015 film The DUFF. Skyler Samuels is currently starring on Fox's horror-comedy TV series, Scream Queens, as Grace Gardner.

http://scream-queens.wikia.com/wiki/Skyler_Samuels