1 Answer

Substance may refer to:

Chemical substance, a material with a definite chemical composition
Drug substance
Substance abuse, drug-related healthcare and social policy diagnosis or label
Substance dependence, drug-related healthcare and social policy diagnosis or label
Matter, anything that has mass and takes up space
Substance theory, theory positing that a substance is distinct from its properties
Substance (Joy Division album), 1988
Substance (Blank & Jones album), 2002
Substance 1987, a New Order album
"Substance", a song by Haste the Day from That They May Know You
Metal Gear Solid 2: Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty
Homoousian, a Christian term meaning "same substance"