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megabus.com does not check luggage or provide receipts for luggage transported on the bus by the passenger.  Customers are advised that megabus.com will accept up to ONE (1) piece of luggage per passenger reservation. For guidance this must not exceed 62 inches when adding the total exterior dimensions of the piece (length + width + height) and should not weigh more than 50 pounds.  Passengers can also take on board one (1) small carry-on bag that will fit in the overhead storage compartments or under the seat. Maximum bag sizes that are commonly used for airline carry-on, such as wheeled rectangular bags are typically too large to be taken on board the bus and will not be permitted in the passenger area. We suggest a bag with dimensions no larger than a briefcase as being about the correct size for carriage onto the bus. All luggage should be locked and we recommend that a TSA approved locking device be used, particularly if crossing international borders. We also recommend that you label your luggage with your name, address and contact number.

From: Megabus.com