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A number of different things can cause a lesion. Lesions are injuries which are characterized by the presence of tissue which does not belong or which grows abnormally. Cancers can cause lesions as can infections and trauma. Like other lesions, kidney lesions are classified as either benign or malignant. A malignant lesion is cancerous and requires treatment. A benign lesion is not cancerous, but may still cause medical complications which lead to treatment.
Source :http://www.wisegeek.org/what-are-kidney-lesions.htm
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